Twitter

Instagram View Richard Barrett-Jolley's profile on LinkedIn
Showing posts with label nuclear DNA. Show all posts
Showing posts with label nuclear DNA. Show all posts

Thursday, 22 August 2013

Blame your mum!

There are a lot of things we know you can do in an attempt to fight off the ravages of time:

Don't smoke

Keep fit

Don't be obese

Eat healthily

Don't fight alligators

Don't let yourself get sunburned

...but that said, a new paper published this week in Nature shows that at least some of your ageing is not your fault, but your mum's! Feel better?

Now the science bit... Everyone knows that we inherit loads of features about ourselves from our DNA. This is of course kept safely inside our cells' control centres (nucleus).... However, each of the cells in our body also contains mitochondria. These are the tiny structures which produce the energy necessary to keep cells working. However, it's increasingly become known that they also have their own supply of DNA. It was quite surprising when that was discovered, but we are now quite certain this is the case. Amazingly, you don't inherit your mitochondria from both parents.... you inherit them only from your mum.

It turns out that this mitochondrial DNA confers some of the differences between ageing rate in people.

Ergo.... Some of your propensity to ageing is inherited directly from your mum!

 

Friday, 28 June 2013

"On no we are not changing the nuclear DNA"... just the mitochondrial.

DNA

On BBC radio news today we were treated to the exciting news that mitochondrial DNA transplants were going to be legal in the UK.  This would, if successfully achieved cure inherited mitochondrial metabolic diseases at a swoop.  
BUT
This horrible pill (?) had to be sweetened with all those statement that this would not be changing "who we are" because it would not touch our DNA.  
Well, lots of things change who we are.  Getting cancer and dying changes who are you, getting cancer and surviving also changes who you are.  It changes who your family is too. All sorts of things change who you are.  All sorts of things change the DNA.
For most diseases we really don't know enough about how the genes go wrong (but frequently we know that they do).  Even if we do... correcting that DNA is coming, but will be tricky. 
But should we change the nuclear DNA if we could??
Hell Yes!